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UK Humanised Mouse Symposium 2018 Programme

UK Humanised Mouse Symposium 2018

Meeting: Friday 23rd March

Pre-Symposium Dinner: Thursday 22nd March 2018 at 19:00

Fitzwilliam College, Storey’s Way, Cambridge, CB3 0DG

 

Symposium Registration Fees: Academia: £25; Industry: £100

Pre-Symposium Dinner: £25

  

Programme

 

08:00

Coffee & Registration

08:50

Welcome & Introduction

Mr Kourosh Saeb-Parsy – University of Cambridge

Session 1 –  Humanised Mouse Models                                     Chair: Prof Giovanna Lombardi

09:00

An introduction to Humanised Mice

Mr Kourosh Saeb-Parsy – University of Cambridge

09:20

Tissue immunophenotyping and cell quantification in humanised mice

Dr Silvia Guionaud - AstraZeneca

09:40

kit mutant (NBSGW) mice as a novel model supporting multilineage human hematopoietic engraftment

Mr George Adigbli  - University of Oxford

10:00

Tools and optimized workflows for the analysis of human cells from humanised mouse models

Dr David Agorku - Miltenyi Biotech

10:30

Coffee

Session 2 – Regenerative Medicine                                               Chair: Prof Renata Stripecke

11:00

Humanised mouse models to study the immunogenicity of iPS-derived cells

Mr Daniel McCluskey – King’s College London

11:20

Feasibility of non-autologous regulatory T cell therapy – assessment in a humanized mouse model

Dr Joanna Hester  - University of Oxford

11:40

Immunogenicity of cholangiocyte immunotherapies

Miss Olivia Tysoe – University of Cambridge

12:00

Human Tregs release extracellular vesicles that protect against human skin allograft damage in humanised mouse models

Miss Sim Tung - Kings College London

12:20

Lunch

Session 3 – Cancer                                                                      Chair: Mr Kourosh Saeb-Parsy

13:00

Immunotoxicology: The need for more predictive in vivo models

Prof Richard Stebbings - MedImmune

13:20

Humanized Mice and Patient-Derived Tumor Xenografts:  A Platform for Immuno-Modulatory Therapeutics

Dr Brian Soper - Jackson Laboratory

14:00

Technological advances in modelling solid and haematological malignancies in humanised mice

Dr Ali Roghanian – University of Southampton

14:30

Coffee

Session 4 – Infection                                                                          Chair: Dr Silvia Guionaud

15:00

Adaptive immune responses against HCMV in humanized mice

Prof Renata Stripecke – Hannover Medical School

15:20

Studying innate immune responses to HBV and HCV in human liver chimeric mice

Dr Ana Maria Ortega-Prieto - Imperial College London

15:40

Virus-Host interactions of HIV in humanized mice

Miss Jessie Skelton - Imperial College London

Session 5 – Round Table Discussion                                           Chair: Prof Richard Stebbings

16:00

What is the ideal method for generation of lymphocyte-reconstituted mice?

Dr Krishnaa Mahbubani, Dr Sarah Howlett and Dr Alba Matas Céspedes  – University of Cambridge & MedImmune

16:50

Summary and Close

Kourosh Saeb-Parsy