UK Humanised Mouse Symposium 2018
Meeting: Friday 23rd March
Pre-Symposium Dinner: Thursday 22nd March 2018 at 19:00
Fitzwilliam College, Storey’s Way, Cambridge, CB3 0DG
Symposium Registration Fees: Academia: £25; Industry: £100
Pre-Symposium Dinner: £25
Programme
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08:00 |
Coffee & Registration |
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08:50 |
Welcome & Introduction |
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Mr Kourosh Saeb-Parsy – University of Cambridge |
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Session 1 – Humanised Mouse Models Chair: Prof Giovanna Lombardi |
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09:00 |
An introduction to Humanised Mice |
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Mr Kourosh Saeb-Parsy – University of Cambridge |
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09:20 |
Tissue immunophenotyping and cell quantification in humanised mice |
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Dr Silvia Guionaud - AstraZeneca |
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09:40 |
kit mutant (NBSGW) mice as a novel model supporting multilineage human hematopoietic engraftment |
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Mr George Adigbli - University of Oxford |
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10:00 |
Tools and optimized workflows for the analysis of human cells from humanised mouse models |
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Dr David Agorku - Miltenyi Biotech |
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10:30 |
Coffee |
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Session 2 – Regenerative Medicine Chair: Prof Renata Stripecke |
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11:00 |
Humanised mouse models to study the immunogenicity of iPS-derived cells |
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Mr Daniel McCluskey – King’s College London |
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11:20 |
Feasibility of non-autologous regulatory T cell therapy – assessment in a humanized mouse model |
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Dr Joanna Hester - University of Oxford |
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11:40 |
Immunogenicity of cholangiocyte immunotherapies |
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Miss Olivia Tysoe – University of Cambridge |
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12:00 |
Human Tregs release extracellular vesicles that protect against human skin allograft damage in humanised mouse models |
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Miss Sim Tung - Kings College London |
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12:20 |
Lunch |
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Session 3 – Cancer Chair: Mr Kourosh Saeb-Parsy |
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13:00 |
Immunotoxicology: The need for more predictive in vivo models |
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Prof Richard Stebbings - MedImmune |
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13:20 |
Humanized Mice and Patient-Derived Tumor Xenografts: A Platform for Immuno-Modulatory Therapeutics |
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Dr Brian Soper - Jackson Laboratory |
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14:00 |
Technological advances in modelling solid and haematological malignancies in humanised mice |
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Dr Ali Roghanian – University of Southampton |
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14:30 |
Coffee |
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Session 4 – Infection Chair: Dr Silvia Guionaud |
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15:00 |
Adaptive immune responses against HCMV in humanized mice |
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Prof Renata Stripecke – Hannover Medical School |
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15:20 |
Studying innate immune responses to HBV and HCV in human liver chimeric mice |
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Dr Ana Maria Ortega-Prieto - Imperial College London |
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15:40 |
Virus-Host interactions of HIV in humanized mice |
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Miss Jessie Skelton - Imperial College London |
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Session 5 – Round Table Discussion Chair: Prof Richard Stebbings |
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16:00 |
What is the ideal method for generation of lymphocyte-reconstituted mice? |
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Dr Krishnaa Mahbubani, Dr Sarah Howlett and Dr Alba Matas Céspedes – University of Cambridge & MedImmune |
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16:50 |
Summary and Close |
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Kourosh Saeb-Parsy |