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UK Humanised Mouse Symposium 2015 Programme

Programme

09:00

Coffee & Registration

Prioress’s Room

 

 

 

19:50

Welcome

Coleridge Room

 

Mr Kourosh Saeb-Parsy & Prof Giovanna Lombardi

 

 

 

 

10:00

An introduction to the generation and use of humanised mice

Coleridge Room

 

Mr Kourosh Saeb-Parsy

 

 

 

 

10:15

Regulation and public perception of humanised mouse research

Coleridge Room

 

Chair: Mr Kourosh Saeb-Parsy & Dr Eleanor Bolton

 

10:15

Humanised mice: Regulatory considerations

 

 

Dr Martin Vinnell – Establishment License Holder at the University of Cambridge

 

10:30

Humanised mice: public engagement and communication

 

 

Mr Tom Holder – Campaign Manager at Understanding Animal Research

 

 

 

 

10:45

Generation and characterisation of humanised mice

Coleridge Room

 

Chair: Prof Giovanna Lombardi & Mr Gavin Pettigrew

 

10:45

Humanised mouse models in transplantation – advantages and pitfalls

 

 

Mr Fadi Issa – University of Oxford

 

11:15

Generation and characterisation of humanised mice from HLA-typed deceased human organ donors

 

 

Mr Kourosh Saeb-Parsy – University of Cambridge

 

11:45

NOD/SCID/IL-2rγ null mice engrafted with human CD34+ stem cells: a model to investigate new strategies to induce tolerance in human islet transplantation

 

 

Dr Fang Xiao – Kings College London

 

12:15

Establishing humanised models of NSG and NOG mice

 

 

Dr Aidan Synnott - Charles River Laboratories

 

 

 

 

13:00

Lunch

Prioress’s Room

 

 

 

14:00

Novel technologies in humanised mouse research

Coleridge Room

 

Chair: Prof Giovanna Lombardi & Mr Kourosh Saeb-Parsy

 

14:00

Innovative preclinical research using humanized NSG Mice

 

 

Dr Brian Soper – Jackson Laboratories

 

14:45

Neurotrophic factors control HSC survival and transplantation

 

 

Dr Henrique Veiga-Fernandes – StemCell2MAX

 

15:15

Isolation and modulation of human HSCs

 

 

Dr Yvonne Diener – Miltenyi Biotec

 

 

 

 

15:45

Coffee

Coleridge Room

 

 

 

16:00

Experimental applications of humanised mice

Coleridge Room

 

Chair: Dr Joanna Hester & Dr Eleanor Bolton

 

16:00

Innate immunity to viral infections in humanised mice

 

 

Dr Marcus Dorner – Imperial College London

 

16:30

Humanised mouse models to study human Tregs in vivo

 

 

Miss Kate Milward – University of Oxford

 

16:45

Using humanised mice to assess the induction of cell expansion by IL-2 and related variants

 

 

Dr Sarah Howlett – University of Cambridge

 

17:00

Generation of allospecific regulatory T cells using chimeric antigen receptors to elicit targeted transplant tolerance

 

 

Mr Dominic Boardman – King’s College London

 

17:15

Humanised mouse model of XenoGvHD to study the stability of human Tregs and the impact of immunosuppressive therapy on their functions

 

 

Dr Cristiano Scotta­ - King’s College London

 

 

 

 

17:30

Summary & Conclusion

Coleridge Room

 

Mr Kourosh Saeb-Parsy