Programme
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09:00 |
Coffee & Registration |
Prioress’s Room |
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19:50 |
Welcome |
Coleridge Room |
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Mr Kourosh Saeb-Parsy & Prof Giovanna Lombardi |
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10:00 |
An introduction to the generation and use of humanised mice |
Coleridge Room |
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Mr Kourosh Saeb-Parsy |
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10:15 |
Regulation and public perception of humanised mouse research |
Coleridge Room |
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Chair: Mr Kourosh Saeb-Parsy & Dr Eleanor Bolton |
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10:15 |
Humanised mice: Regulatory considerations |
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Dr Martin Vinnell – Establishment License Holder at the University of Cambridge |
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10:30 |
Humanised mice: public engagement and communication |
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Mr Tom Holder – Campaign Manager at Understanding Animal Research |
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10:45 |
Generation and characterisation of humanised mice |
Coleridge Room |
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Chair: Prof Giovanna Lombardi & Mr Gavin Pettigrew |
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10:45 |
Humanised mouse models in transplantation – advantages and pitfalls |
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Mr Fadi Issa – University of Oxford |
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11:15 |
Generation and characterisation of humanised mice from HLA-typed deceased human organ donors |
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Mr Kourosh Saeb-Parsy – University of Cambridge |
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11:45 |
NOD/SCID/IL-2rγ null mice engrafted with human CD34+ stem cells: a model to investigate new strategies to induce tolerance in human islet transplantation |
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Dr Fang Xiao – Kings College London |
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12:15 |
Establishing humanised models of NSG and NOG mice |
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Dr Aidan Synnott - Charles River Laboratories |
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13:00 |
Lunch |
Prioress’s Room |
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14:00 |
Novel technologies in humanised mouse research |
Coleridge Room |
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Chair: Prof Giovanna Lombardi & Mr Kourosh Saeb-Parsy |
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14:00 |
Innovative preclinical research using humanized NSG Mice |
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Dr Brian Soper – Jackson Laboratories |
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14:45 |
Neurotrophic factors control HSC survival and transplantation |
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Dr Henrique Veiga-Fernandes – StemCell2MAX |
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15:15 |
Isolation and modulation of human HSCs |
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Dr Yvonne Diener – Miltenyi Biotec |
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15:45 |
Coffee |
Coleridge Room |
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16:00 |
Experimental applications of humanised mice |
Coleridge Room |
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Chair: Dr Joanna Hester & Dr Eleanor Bolton |
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16:00 |
Innate immunity to viral infections in humanised mice |
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Dr Marcus Dorner – Imperial College London |
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16:30 |
Humanised mouse models to study human Tregs in vivo |
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Miss Kate Milward – University of Oxford |
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16:45 |
Using humanised mice to assess the induction of cell expansion by IL-2 and related variants |
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Dr Sarah Howlett – University of Cambridge |
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17:00 |
Generation of allospecific regulatory T cells using chimeric antigen receptors to elicit targeted transplant tolerance |
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Mr Dominic Boardman – King’s College London |
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17:15 |
Humanised mouse model of XenoGvHD to study the stability of human Tregs and the impact of immunosuppressive therapy on their functions |
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Dr Cristiano Scotta - King’s College London |
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17:30 |
Summary & Conclusion |
Coleridge Room |
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Mr Kourosh Saeb-Parsy |
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